General Recommendations Antigen tests are immunoassays which detect the presence or absence of a specific viral antigen. This indicates that someone is infected. Testing for antigens is possible on nasal swab samples that have been directly injected in the extraction buffer or reagent. The current approval of antigen tests is for use in many tests, including laboratory-based, self-testing, and point-of-care. They can be used by anyone of any age. When used to screen, both the antigen test results and NAATs must be correctly interpreted. This will allow for accurate treatment of patients and people suspected of having COVID-19. It also allows for diagnosis of infected persons. The circumstances under which antigen rapid diagnostic tests are administered or performed can greatly impact their clinical performance. Both antigen tests and NAATs are most effective when the viral load of the patient is at its highest. Antigen tests work best when people are symptomatic and within a speci...
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